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Editorial: Health effects and pathophysiological mechanisms of one-carbon metabolism nutrients intake throughout the life cycle

The methodological quality of the included studies, as assessed through the Jadad and Newcastle–Ottawa scales, varied from moderate to high, while the GRADE assessment indicated moderate certainty of evidence for serum vitamin B12 increase and low certainty for homocysteine reduction

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He will also ask about any underlying health conditions that can impact B12 absorption, such as digestive disorders (like Crohn’s disease or celiac disease), past surgeries (including gastric bypass), or dietary patterns common in families, such as vegetarian or vegan diets